Prof. Chan’s research interest has been on clinical neuropsychology and neuropsychological intervention. She has published in top-ranking journals including Nature. One area of her research addresses the underlying nature of cognitive impairment associated with autism and dementia, and her laboratory has utilized electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) as means to understand the neural processing of various cognitive impairments. Another area of research is to develop neurocognitive modulation methods to improve cognitive functions. A recent investigation is to integrate the Chinese Chan medical concept as a possible neuro-psychological intervention for individuals with autism, depression, and elderly with memory problems.